PARATİROİD ADENOM AĞIRLIKLARININ VE OKSİFİL HÜCRE İÇERİKLERİNİN SESTAMİBİ SİNTİGRAFİSİNE ETKİSİ

Başlık: PARATİROİD ADENOM AĞIRLIKLARININ VE OKSİFİL HÜCRE İÇERİKLERİNİN SESTAMİBİ SİNTİGRAFİSİNE ETKİSİ
Yazar: Taylan Çelik
Yazar-email:
Kurum: İSTANBUL ÜNİVERSİTESİ İSTANBUL TIP FAKÜLTESİ GENEL CERRAHİ ANABİLİM DALI
Yil: 2009
Anahtar:
Ozet: Although the sensitivity of sestamibi scanning is high in solitary parathyroid adenomas, negative sestamibi scans are inevitable. The exact mechanism of visualization of abnormal and hyperfunctioning parathyroid tissue is not yet clear. The aims of this clinical study are to evaluate positive and negative sestamibi scan results with regard to the adenoma weight and the oxyphil cell content, and to compare the effects of the adenoma weight and the oxyphil cell content on the results of sestamibi scanning.
The patients were divided in two groups according to their sestamibi scan results. Group 1 consisted of 27 patients with positive sestamibi scans and group 2 consisted of 20 patients with negative sestamibi scans. Parathyroid adenoma weight and oxyphil cell content were determined in all patients.
The weight and the oxyphil cell content of the parathyroid adenomas in the patients of group 1 were significantly higher than those of the patients of group 2 (p=0.001). An adenoma weight more than 600 mg and an oxyphil cell content of more than 20% increased the rate of obtaining a positive sestamibi scan 10-fold and 4-fold, respectively (OR: 10.6; 95% CI: 2.6-43.4 and OR: 4.3; 95% CI: 1.13-16.2).
Both the adenoma weight and the oxyphil cell content were found to significantly correlate with a positive sestamibi scan. In patients with high-weight adenomas, the adenoma weight was the most significant factor, whereas in patients with low adenoma weights, a high oxyphil cell content was the most significant factor in obtaining a positive MIBI scan result.
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